The partition coefficient of the ester in question is important because is effects how long the drug itself stays in the system. If the testosterone transfers too quickly from the oil to the blood, the result is a sudden spike in testosterone which then rapidly drops once the dose has been used up. In the example of free testosterone injected into the muscle from a water suspension (as in Aquiviron, mentioned above), the testosterone is essentially immediately available to the bloodstream due to its low partition coefficient, and thus there is an immediate spike of testosterone which is used up quickly in the body.
dose-response relationships in healthy young men;
and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression
of clomiphene citrate to reverse premature andropause secondary to steroid abuse.
in the Endocrinological Milieu After Clomiphene Citrate Treatment for Oligozoospermia: The Clinical Significance of the Estradiol/Testosterone Ratio as a Prognostic Value
steroidogenesis after human chorionic gonadotropin desensitization in rats.
of tamoxifen on GH and IGF-1 serum level in stage I-II breast cancer patients
of gynecomastia with tamoxifen: A double-blind crossover study
of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men.
A 2006 study determined that 1-testosterone has a high androgenic and anabolic potency even without being metabolized, so it can be characterized as a typical anabolic steroid. 1-Testosterone binds in a manner that is highly selective to the androgen receptor (AR) and has a high potency to stimulate AR-dependent transactivation . In vivo , an equimolar dose of 1-testosterone has the same potency to stimulate the growth of the prostate , the seminal vesicles and the androgen-sensitive levator ani muscle as the reference anabolic steroid testosterone propionate , but, unlike testosterone propionate, 1-testosterone also increases liver weight.