Ingredients: Whole wheat flour, water, wheat gluten, whole buckwheat groats, contains 2% or less of the following: whole amaranth, whole spelt flakes, whole kamut (khorasan wheat), whole quinoa flakes, whole grain buckwheat flour, oat fiber, polydextrose, salt, sugarcane fiber, wheat bran, molasses, soybean and/or canola oil , yeast, sodium stearoyl lactylate , vinegar , calcium propionate (preservative) , calcium sulfate, ethoxylated mono- and diglycerides , DATEM , citric acid , azodicarbonamide , acesulfame potassium , soy flour .
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In propionic acidemia , a rare inherited genetic disorder, propionate acts as a metabolic toxin in liver cells by accumulating in mitochondria as propionyl-CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Propanoate is metabolized oxidatively by glia , which suggests astrocytic vulnerability in propionic acidemia when intramitochondrial propionyl-CoA may accumulate. Propionic acidemia may alter both neuronal and glial gene expression by affecting histone acetylation.   When propionic acid is infused directly into rodents' brains, it produces reversible behavior (., hyperactivity , dystonia , social impairment, perseveration ) and brain changes (., innate neuroinflammation, glutathione depletion) that may be used as a means to model autism in rats.